2-Phenyl-1,3-dioxolane-2-acetic acid ethyl ester

Base Information

• Chemical Name: 2-Phenyl-1,3-dioxolane-2-acetic acid ethyl ester
• CAS No.: 27773-03-1
• Molecular Formula: C13H16O4
• Molecular Weight: 236.268
• Hs Code.: 2932999099
• Mol file: 27773-03-1.mol

Synonyms:(2-phenyl-[1,3]dioxolan-2-yl)-acetic acid ethyl ester;ethyl benzoylacetate ethylene ketal;ethyl 3,3-ethylenedioxy-3-phenylpropanoate;ethyl 2-(2-phenyl-1,3-dioxolan-2-yl)acetate;

Chemical Property of 2-Phenyl-1,3-dioxolane-2-acetic acid ethyl ester

Chemical Property:

• PSA: 44.76000
• LogP: 1.83940

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-1,3-dioxolane-2-acetic acid ethyl ester

There total 3 articles about 2-Phenyl-1,3-dioxolane-2-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + ethylene glycol (107-21-1) → ethyl 3,3-(ethylenedioxy)-3-phenylpropanoate (27773-03-1)

Guidance literature:

toluene-4-sulfonic acid; In benzene; Heating; Dean-Stark apparatus;

Reference yield:

Ethyl 3-hydroxy-3-phenylpropanoate (5764-85-2) → ethyl 3,3-(ethylenedioxy)-3-phenylpropanoate (27773-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / CrO₃; pyridine / CH₂Cl₂ / 20 °C

2: 73 percent / p-TsOH / benzene / 15 h / Heating

With pyridine; chromium(VI) oxide; toluene-4-sulfonic acid; In dichloromethane; benzene; 1: Collins oxidation;

DOI:10.1002/jhet.5570380124

Reference yield:

→ ethyl 3,3-(ethylenedioxy)-3-phenylpropanoate (27773-03-1)

Guidance literature:

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

ethylene glycol

Ethyl 3-hydroxy-3-phenylpropanoate

Downstream raw materials:

2-(2-phenyl-1,3-dioxolan-2-yl)acetic acid

2-(2-hydroxyethyl)-2-phenyl-1,3-dioxolane

(2R)-2-Amino-4-oxo-4-phenylbutyric acid

(S)-2-amino-4-oxo-4-phenyl-butanoic acid