Cyclohexanamine, N-(phenylmethylene)-, (E)-

Base Information

• Chemical Name: Cyclohexanamine, N-(phenylmethylene)-, (E)-
• CAS No.: 27845-53-0
• Molecular Formula: C13H17N
• Molecular Weight: 187.285
• Mol file: 27845-53-0.mol

Synonyms:

Chemical Property of Cyclohexanamine, N-(phenylmethylene)-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanamine, N-(phenylmethylene)-, (E)-

There total 12 articles about Cyclohexanamine, N-(phenylmethylene)-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

cyclohexylamine (108-91-8,157973-60-9) + benzylamine (100-46-9) → (E)-N-cyclohexyl-1-phenylmethanimine (27845-53-0) + (E)-N-benzylidenebenzylamine (27845-50-7)

Guidance literature:

With C₁₄H₁₄N₂⁽¹⁺⁾*BF₄^(1-); oxygen; In neat (no solvent); at 100 ℃; under 750.075 Torr; Schlenk technique;

DOI:10.1021/acs.joc.8b02345

Reference yield: 99.0%

N-benzoylcyclohexylamine (1759-68-8) → (E)-N-cyclohexyl-1-phenylmethanimine (27845-53-0)

Guidance literature:

With triethyl borane; phenylsilane; potassium tert-butylate; In tetrahydrofuran; at 80 ℃; for 48h; chemoselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/acs.joc.9b00277

Reference yield: 90.0%

N-benzylcyclohexylamine (4383-25-9) → (E)-N-cyclohexyl-1-phenylmethanimine (27845-53-0) + benzaldehyde (100-52-7)

Guidance literature:

With tert.-butylhydroperoxide; dirhodium(II) tetrakis(caprolactam); In decane; acetonitrile; at 20 ℃; for 16h; Further Variations:; Solvents; Product distribution;

DOI:10.1039/b615805f

upstream raw materials:

cyclohexylamine

benzaldehyde

Benzoylformic acid

benzyl alcohol

Downstream raw materials:

Cyclohexyl-(2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoro-1-phenyl-heptyl)-amine

N,N'-dicyclohexyl-1,2-diphenyl-1,2-ethylendiamin

N,N'-dicyclohexyl-1,2-diphenyl-1,2-ethanediamine

N,N'-dicyclohexyl-1,2-diphenyl-1,2-ethanediamine

Refernces

• 1、 Aispuro-Pérez, Analy,Bastidas, Pedro,Calderón-Zamora, Loranda,García-Páez, Fernando,López-ávalos, Juan,Monta?o, Sarita,Montes-Avila, Julio,Ochoa-Terán, Adrián,Osuna-Martínez, Ulises,Picos-Corrales, Lorenzo A.,Sarmiento-Sánchez, Juan I.. "Synthesis and molecular docking studies of imines as α-glucosidase and α-amylase inhibitors". . . Retrieved 2019/12/25.
• 2、 Chai, Huining,Yu, Kun,Liu, Bo,Tan, Weiqiang,Zhang, Guangyao. "A Highly Selective Manganese-Catalyzed Synthesis of Imines under Phosphine-Free Conditions". . p. 217 - 226. Retrieved 2020/01/31.