Benzeneacetic acid, 2-hydroxyethyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 2-hydroxyethyl ester
• CAS No.: 28481-53-0
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol file: 28481-53-0.mol

Synonyms:

Chemical Property of Benzeneacetic acid, 2-hydroxyethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, 2-hydroxyethyl ester

There total 15 articles about Benzeneacetic acid, 2-hydroxyethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + ethylene glycol (107-21-1) → 2-hydroxyethyl 2-phenylacetate (28481-53-0)

Guidance literature:

With iodine; In 1,4-dioxane; at 20 ℃; for 24h; Mechanism;

DOI:10.1039/c3cc38085h

Reference yield: 82.0%

phenylacetic acid (103-82-2) + ethylene glycol (107-21-1) → 2-hydroxyethyl 2-phenylacetate (28481-53-0)

Guidance literature:

With aluminum oxide; methanesulfonic acid; at 80 ℃; for 2h;

DOI:10.1016/S0040-4020(03)00518-0

Reference yield: 81.0%

2-(benzyl)-1,3-dioxolane (101-49-5) → 2-hydroxyethyl 2-phenylacetate (28481-53-0)

Guidance literature:

With tetraethylammonium bromide; water; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; at 65 ℃; for 2h;

DOI:10.1055/s-0028-1087986

upstream raw materials:

phenylacetic acid

ethylene glycol

potassium phenylacetate

2-chloro-ethanol

Downstream raw materials:

N-tert-butylphenylacetamide

N-[(1S)-1-phenylethyl]-benzeneacetamide

N-2-methoxyethyl 2-phenylacetamide

N-benzylphenylacetamide