4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline

Base Information

• Chemical Name: 4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline
• CAS No.: 286371-44-6
• Molecular Formula: C17H15ClN2O3
• Molecular Weight: 330.771
• Mol file: 286371-44-6.mol

Synonyms:4-[(4-amino-3-chlorophenyl)oxy]-6,7-dimethoxyquinoline;2-chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline;2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline;4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-chloroaniline;2-chloro-4-(6,7-dimethoxyquinolin-4-yloxy)benzenamine;

Chemical Property of 4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline

Chemical Property:

• Boiling Point: 491.8±45.0 °C(Predicted)
• PKA: 5.59±0.30(Predicted)
• PSA: 66.60000
• Density: 1.325±0.06 g/cm3(Predicted)
• LogP: 4.86110

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline

There total 13 articles about 4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6,7-dimethoxy-4-chloroquinoline (35654-56-9) + 4-Amino-3-chlorophenol hydrochloride (52671-64-4) → 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-chloroaniline (286371-44-6)

Guidance literature:

4-Amino-3-chlorophenol hydrochloride; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

6,7-dimethoxy-4-chloroquinoline; In dimethyl sulfoxide; at 110 ℃; for 12h;

DOI:10.1021/jm030427r

Reference yield: 85.0%

6,7-dimethoxy-4-chloroquinoline (35654-56-9) + 4-amino-3-chlorophenol (17609-80-2) → 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-chloroaniline (286371-44-6)

Guidance literature:

4-amino-3-chlorophenol; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.333333h;

6,7-dimethoxy-4-chloroquinoline; In dimethyl sulfoxide; at 110 ℃;

DOI:10.1021/acs.jmedchem.9b00280

Reference yield: 82.7%

6,7-dimethoxyquinoline-4-ol (13425-93-9) + C18H13ClNS(1+)*CF3O3S(1-) → 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-chloroaniline (286371-44-6)

Guidance literature:

With caesium hydroxide; In 1,4-dioxane; at 50 ℃; for 12h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere; Glovebox;

upstream raw materials:

6,7-dimethoxy-4-chloroquinoline

4-Amino-3-chlorophenol hydrochloride

2-amino-4,5-dimethoxyacetophenone

1,4-dihydro-6,7-dimethoxy-4-oxoquinoline

Downstream raw materials:

ethyl 2-{2-[({2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]anilino}carbonyl)amino]-1,3-thiazol-4-yl}acetate

tivozanib

N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-methylphenyl)urea

N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(2-methoxyphenyl)urea