2-Phenoxypyridin-3-amine

Base Information

• Chemical Name: 2-Phenoxypyridin-3-amine
• CAS No.: 28664-62-2
• Molecular Formula: C11H10N2O
• Molecular Weight: 186.213
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10588561
• Wikidata: Q82481304
• Mol file: 28664-62-2.mol

Synonyms:2-phenoxypyridin-3-amine;28664-62-2;2-Phenoxy-3-pyridinamine;2-phenoxy-3-aminopyridine;2-Phenoxy-pyridin-3-ylamine;SCHEMBL243134;DTXSID10588561;GITFEFNVRNPOHX-UHFFFAOYSA-N;BBL031429;MFCD09738154;STL253607;AKOS000145639;MCULE-6660250058;SB52775;TS-02601;DB-347302;CS-0247593;EN300-36953;F78913;A1-02646;F1907-0394;Z240084488

Chemical Property of 2-Phenoxypyridin-3-amine

Chemical Property:

• PSA: 48.14000
• LogP: 3.03730
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 186.079312947
• Heavy Atom Count: 14
• Complexity: 169

Purity/Quality:

99%, ^*data from raw suppliers

2-Phenoxypyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=C(C=CC=N2)N

Technology Process of 2-Phenoxypyridin-3-amine

There total 6 articles about 2-Phenoxypyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-nitropyridine-2-phenyl ether (76893-44-2) → 3-amino-2-phenoxypyridine (28664-62-2)

Guidance literature:

With palladium on carbon; hydrogen; In ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2010.10.004

Reference yield:

phenol (108-95-2,27073-41-2) → 3-amino-2-phenoxypyridine (28664-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2: zinc; ammonium chloride / ethanol; ethyl acetate / 20 °C / Inert atmosphere

With ammonium chloride; caesium carbonate; zinc; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm301708u

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 3-amino-2-phenoxypyridine (28664-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2: zinc; ammonium chloride / ethanol; ethyl acetate / 20 °C / Inert atmosphere

With ammonium chloride; caesium carbonate; zinc; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm301708u

upstream raw materials:

3-nitropyridine-2-phenyl ether

2-fluoro-3-nitropyridine

phenol

2-Chloro-3-nitropyridine

Downstream raw materials:

C₂₁H₁₉BrN₂O₃

C₂₁H₁₉⁽¹⁸⁾FN₂O₃

N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide

N-[2-(2-fluoroethoxy)-5-methoxybenzyl]-N-(2-phenoxypyridin-3-yl)acetamide