N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide

Base Information

• Chemical Name: N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide
• CAS No.: 1245623-84-0
• Molecular Formula: C₂₂H₂₁FN₂O₃
• Molecular Weight: 380.419
• Mol file: 1245623-84-0.mol

Synonyms:

Chemical Property of N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide

There total 8 articles about N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-2-phenoxypyridine (28664-62-2) → N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide (1245623-84-0)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 1 h / 90 °C / Inert atmosphere

2: pyridine / dichloromethane / 18 h / 20 °C / Inert atmosphere

3: sodium hydroxide / methanol / 0.5 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 1 h / 30 °C / Inert atmosphere

With pyridine; sodium hydride; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

phenol (108-95-2,27073-41-2) → N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide (1245623-84-0)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: hydrogen; palladium on activated charcoal / methanol / 2 h / 30 °C

3: toluene / 1 h / 90 °C / Inert atmosphere

4: pyridine / dichloromethane / 18 h / 20 °C / Inert atmosphere

5: sodium hydroxide / methanol / 0.5 h / 20 °C

6: sodium hydride / N,N-dimethyl-formamide / 1 h / 30 °C / Inert atmosphere

With pyridine; palladium on activated charcoal; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

3-nitropyridine-2-phenyl ether (76893-44-2) → N-[2-(2-fluoroethoxy)benzyl]-N-(2-phenoxy pyridin-3-yl)acetamide (1245623-84-0)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen; palladium on activated charcoal / methanol / 2 h / 30 °C

2: toluene / 1 h / 90 °C / Inert atmosphere

3: pyridine / dichloromethane / 18 h / 20 °C / Inert atmosphere

4: sodium hydroxide / methanol / 0.5 h / 20 °C

5: sodium hydride / N,N-dimethyl-formamide / 1 h / 30 °C / Inert atmosphere

With pyridine; palladium on activated charcoal; hydrogen; sodium hydride; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-fluoro-3-nitropyridine

phenol

3-nitropyridine-2-phenyl ether

3-amino-2-phenoxypyridine