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Basic Information
CAS No.: 58-40-2
Name: Promazine
Molecular Structure:
Molecular Structure of 58-40-2 (Promazine)
Formula: C17H20 N2 S
Molecular Weight: 284.425
Synonyms: Phenothiazine,10-[3-(dimethylamino)propyl]- (8CI); 10-[3-(Dimethylamino)propyl]phenothiazine;3276RP; A 145; Ampazine; Berophen; Esparin;N-(3-Dimethylaminopropyl)phenothiazine; NSC 31447; Neo-Hibernex; Prazin;Prazine; Promazine; Protactyl; RP 3276; Romtiazin; Sinophenin; Tomil; Verophen;Wy 1094
EINECS: 200-382-0
Density: 1.133g/cm3
Melting Point: 25°C
Boiling Point: 412.7°Cat760mmHg
Flash Point: 203.4°C
Solubility: 14.22mg/L(24 oC)
Safety: Human poison by unspecified route. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.
PSA: 31.78000
LogP: 4.30600
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Chemistry

IUPAC Name: N,N-Dimethyl-3-phenothiazin-10-ylpropan-1-amine
The MF of Promazine (CAS NO.58-40-2) is C17H20N2S.

                     
The MW of Promazine (CAS NO.58-40-2) is 284.4191.
Synonyms of Promazine (CAS NO.58-40-2): 10-(3-Dimethylaminopropyl)phenothiazine ; 10H-Phenothiazine-10-propanamine, N,N-dimethyl- ; Phenothiazine, 10-[3- (dimethylamino)propyl]-
Index of Refraction: 1.617 
EINECS: 200-382-0
Density: 1.133 g/ml 
Flash Point: 203.4 °C
Boiling Point: 412.7 °C

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 140mg/kg (140mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965.
mouse LD50 intravenous 45mg/kg (45mg/kg) BEHAVIORAL: SLEEP Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 87, 1962.
mouse LD50 oral 401mg/kg (401mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 489, 1958.
mouse LD50 subcutaneous 110mg/kg (110mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR		 Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rabbit LD50 intravenous 21mg/kg (21mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat LD50 intravenous 14500ug/kg (14.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGES IN CIRCULATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 311, 1959.
rat LD50 oral 350mg/kg (350mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 507, 1958.
rat LD50 subcutaneous 192mg/kg (192mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR		 Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rat LDLo intraperitoneal 210mg/kg (210mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Human poison by unspecified route. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.