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Cas Database

Name	Promazine	EINECS	200-382-0
CAS No.	58-40-2	Density	1.133g/cm³
PSA	31.78000	LogP	4.30600
Solubility	14.22mg/L(24 oC)	Melting Point	25°C
Formula	C17H20 N2 S	Boiling Point	412.7°Cat760mmHg
Molecular Weight	284.425	Flash Point	203.4°C
Transport Information	N/A	Appearance	N/A
Safety	Human poison by unspecified route. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Phenothiazine,10-[3-(dimethylamino)propyl]- (8CI); 10-[3-(Dimethylamino)propyl]phenothiazine;3276RP; A 145; Ampazine; Berophen; Esparin;N-(3-Dimethylaminopropyl)phenothiazine; NSC 31447; Neo-Hibernex; Prazin;Prazine; Promazine; Protactyl; RP 3276; Romtiazin; Sinophenin; Tomil; Verophen;Wy 1094	Article Data	24

Promazine Chemical Properties

IUPAC Name: N,N-Dimethyl-3-phenothiazin-10-ylpropan-1-amine
The MF of Promazine (CAS NO.58-40-2) is C₁₇H₂₀N₂S.

The MW of Promazine (CAS NO.58-40-2) is 284.4191.
Synonyms of Promazine (CAS NO.58-40-2): 10-(3-Dimethylaminopropyl)phenothiazine ; 10H-Phenothiazine-10-propanamine, N,N-dimethyl- ; Phenothiazine, 10-[3- (dimethylamino)propyl]-
Index of Refraction: 1.617
EINECS: 200-382-0
Density: 1.133 g/ml
Flash Point: 203.4 °C
Boiling Point: 412.7 °C

Promazine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	140mg/kg (140mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965.
mouse	LD50	intravenous	45mg/kg (45mg/kg)	BEHAVIORAL: SLEEP	Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 87, 1962.
mouse	LD50	oral	401mg/kg (401mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 489, 1958.
mouse	LD50	subcutaneous	110mg/kg (110mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rabbit	LD50	intravenous	21mg/kg (21mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat	LD50	intravenous	14500ug/kg (14.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGES IN CIRCULATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 311, 1959.
rat	LD50	oral	350mg/kg (350mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 507, 1958.
rat	LD50	subcutaneous	192mg/kg (192mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR	Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1798, 1974.
rat	LDLo	intraperitoneal	210mg/kg (210mg/kg)		Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.

Promazine Consensus Reports

EPA Genetic Toxicology Program.

Promazine Safety Profile

Human poison by unspecified route. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.

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