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| CAS No.: | 363-24-6 |
|---|---|
| Name: | Prostaglandin E2 |
| Molecular Structure: | |
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|
|
| Formula: | C20H32O5 |
| Molecular Weight: | 352.471 |
| Synonyms: | 5-Heptenoicacid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- (8CI);(-)-Prostaglandin E2;(15S)-Prostaglandin E2;11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (5Z,11a,13E,15S);11a,15a-Dihydroxy-9-oxo-5-cis,13-trans-prostadienoic acid;Cervidil;Cerviprime;Dinoprostone;Enzaprost E;Minprositin E2;NSC 196514;PGE2;Primiprost;Prostaglandin E2;Prostenon;Prostenone;Prostin (prostaglandin);U 12062;Vivelle-Dot;l-Prostaglandin E2; |
| EINECS: | 206-656-6 |
| Density: | 1.148 g/cm3 |
| Melting Point: | 66-68 °C |
| Boiling Point: | 530.1 °C at 760 mmHg |
| Flash Point: | 288.5 °C |
| Solubility: | ethanol: 1 mg/mL |
| Appearance: | white to pale yellowish-cream powder |
| Hazard Symbols: |
 T
|
| Risk Codes: | 60-22 |
| Safety: | 53-22-26-36/37/39 |
| PSA: | 94.83000 |
| LogP: | 3.25110 |
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Chemistry
Molecular Formula:C20H32O5
Molecular Weight:352.52
EINECS:206-656-6
Density:1.148g/cm3
Melting Point:66-68°C
Boiling Point:530.1°Cat760mmHg
Flash Point:288.5°C
Solubility:insoluble
Properties:Crystals
Dinoprostone's Synonyms: Prostaglandin E2;9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid;(5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID;PROSTAGLANDIN;PROSTAGLANDIN E2
Uses
Induction of labor
Toxicity Data With Reference
| 1. | oms-mus:oth 100 nmol/L | JIDEAE Journal of Investigative Dermatology. 66 (1976),313. | ||
| 2. | spm-mus-ipr 3 mg/kg | INJFA3 International Journal of Fertility. 21 (1976),82. | ||
| 3. | dns-gpg:lng 1 mg/L | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 171 (1982),109. | ||
| 4. | orl-rat LD50:500 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 8 (1974),787. | ||
| 5. | scu-rat LD50:31,600 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 8 (1974),787. | ||
| 6. | ivn-rat LD50:59,500 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 8 (1974),787. | ||
| 7. | orl-mus LD50:750 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 8 (1974),787. | ||
| 8. | scu-mus LD50:19,700 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 8 (1974),787. | ||
| 9. | ivn-mus LD50:23,200 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 8 (1974),787. | ||
| 10. | ipr-ham LD50:1 mg/kg | PLMEDD Prostaglandins, Leukotrienes and Medicine. 17 (1985),309. |
Safety Profile
Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by intravenous, intraplacental, and intravaginal routes: changes in the uterus, cervix and vagina; termination of pregnancy; and changes in fertility. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Dinoprostone's Safety Information
Hazard Codes T
Risk Statements 60-22
Safety Statements 53-22-26-36/37/39
WGK Germany 3
RTECS UK8000000
F 8-10
Specification
Dinoprostone's Handling and Storage
【Storage】Keep container closed when not in use. Deep freeze (below -20 C). Store protected from light. Store with dessicant.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Use only in a chemical fume hood.