Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

STREPTONIVICIN

Related Products

Hot Products

Name

STREPTONIVICIN

EINECS N/A
CAS No. 303-81-1 Density 1.42g/cm3
PSA 200.01000 LogP 4.40040
Solubility N/A Melting Point 170-172 °C
Formula C31H36 N2 O11 Boiling Point 848.2°Cat760mmHg
Molecular Weight 612.634 Flash Point 466.8°C
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal route. Moderately toxic by ingestion and intravenous routes. Human systemic effects by unspecified route: conjunctiva irritation and skin dermatitis. Human mutation data reported. An antibiotic with serious side effects which include liver and blood disease. It may also cause the development of resistant strains of staphylococcus. Used as a food additive permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals; also permitted in food for human consumption. When heated to decomposition it emits toxic fumes of NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 303-81-1 (Novobiocin) Hazard Symbols May have damaging side effects.
Synonyms

Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-(9CI); Coumarin, 7-[4-(carbamoyloxy)tetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yloxy]-4-hydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)benzamido]-8-methyl-(6CI); Novobiocin (8CI); Albamix; Albamycin; Antibiotic PA-93; Cardelmycin;Cathocin; Cathomycin; Crystallinic acid; Inamycin; Novo-R; PA 93; Robiocina; Sirbiocina;Spheromycin; Stilbiocina; Streptonivicin; U 6391

Article Data 9

STREPTONIVICIN Chemical Properties

Formula: C31H36N2O11 
Mol. mass: 612.624

STREPTONIVICIN Uses

STREPTONIVICIN (303-81-1) may be used to differentiate from the other coagulase-negative Staphylococcus saprophyticus, which is resistant to novobiocin, in culture.
STREPTONIVICIN (303-81-1) is effective antistaphylococcal agent used in the treatment of MRSA.

STREPTONIVICIN Production

The 3-dimethylallyl-4-hydroxybenzoic acid moiety, known as ring A, is derived from prephenate and dimethylallyl pyrophosphate. The aminocoumarin moiety, known as ring B, is derived from L-Tyrosine. The final component of STREPTONIVICIN (303-81-1) is the sugar derivative L-noviose, known as ring C, which is derived from glucose-1-phosphate. Rings A, B, and C are coupled together and modified to give the finished STREPTONIVICIN (303-81-1) molecule.

STREPTONIVICIN Toxicity Data With Reference

1.   

mmo-esc 200 mg/L

   NATUAS    Nature. 271 (1978),385.
2.   

pic-esc 10 µg/plate

   CNREA8    Cancer Research. 43 (1983),2819.
3.   

dni-hmn:emb 600 mmol/L

   CRNGDP    Carcinogenesis. 3 (1982),1171.
4.   

cyt-mus-par 50 mg/kg

   NULSAK    Nucleus (Calcutta). 2 (1971),161.
5.   

dnr-ham:oth 200 mg/L

   CRNGDP    Carcinogenesis. 5 (1984),187.
6.   

unr-hmn TDLo:171 mg/kg/12D-C:EYE,SKN

   85ERAY    Antibiotics: Origin, Nature, and Properties. 1 (1978),137.
7.   

orl-mus LD50:1500 mg/kg

   85GDA2    CRC Handbook of Antibiotic Compounds, Volumes 1-9. 6 (1981),338.
8.   

ipr-mus LD50:262 mg/kg

   85FZAT    Index of Antibiotics from Actinomycetes Umezawa, H., et al., eds.,Tokyo, Japan.: University of Tokyo Press,1967,471.
9.   

ivn-mus LD50:407 mg/kg

   85FZAT    Index of Antibiotics from Actinomycetes Umezawa, H., et al., eds.,Tokyo, Japan.: University of Tokyo Press,1967,471.

STREPTONIVICIN Safety Profile

STREPTONIVICIN (303-81-1)  is poison by intraperitoneal route. Moderately toxic by ingestion and intravenous routes. Human systemic effects by unspecified route: conjunctiva irritation and skin dermatitis. Human mutation data reported. An antibiotic with serious side effects which include liver and blood disease. STREPTONIVICIN (303-81-1) may also cause the development of resistant strains of staphylococcus. Used as a food additive permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals; also permitted in food for human consumption. When heated to decomposition it emits toxic fumes of NOx.
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 303-81-1