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| CAS No.: | 66-32-0 |
|---|---|
| Name: | STRYCHNINE NITRATE |
| Molecular Structure: | |
|
|
|
| Formula: | C21H22N2O2•HNO3 |
| Molecular Weight: | 397.431 |
| Synonyms: | Strychninenitrate;98.5% |
| EINECS: | 200-627-1 |
| Density: | 1.6270 |
| Melting Point: | 295°C |
| Boiling Point: | 634.3 °C at 760 mmHg |
| Flash Point: | 337.4 °C |
| Hazard Symbols: |
 T+
|
| Risk Codes: | 26/27/28 |
| Safety: | Poison by ingestion, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx. See also STRYCHNINE. |
| Transport Information: | UN 1692 6 |
| PSA: | 98.83000 |
| LogP: | 2.27090 |
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Chemistry
Product Name: Strychnine nitrate (66-32-0)
Synonyms: Strychnine nitrate ; Strychnine nitrate salt ; Strychnidin-10-one,mononitrate ; Strychnine,mononitrate ; Strychninenitrate,(L-A044) ; StrychnineHCL,(L-A046) ; Strychnine nitrate : 98.5%
CAS: 66-32-0
MF: C21H23N3O5
MW: 397.42
MS: 
EINECS: 200-627-1
Product Categories: Alkaloids;Biochemistry;for Resolution of Acids;Indole Alkaloids;Optical Resolution;Synthetic Organic Chemistry;Asymmetric Synthesis;Chiral Building Blocks;Complex Molecules
Mol File: 66-32-0.mol
Merck: 8855
Flash Point: 337.4 °C
Enthalpy of Vaporization: 98.54 kJ/mol
Boiling Point: 634.3 °C at 760 mmHg
Vapour Pressure: 5.83E-17 mmHg at 25°C
Uses
1.Categories :Strychnine mononitrate (66-32-0) belongs to toxic substances
2.Toxicity: grading toxic
3.Acute oral toxicity :- rat LD50 16.2 mg / kg; Oral - Mouse LD50: 0.93 mg / kg
4.Flammable combustible hazardous properties; Decomposition of fumes of toxic nitrogen oxides.
5.Warehouse storage and transport : low temperature, ventilation, drying; and separately from raw materials of food
6.Extinguishing agents :water, carbon dioxide, dry powder, sand
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| cat | LDLo | oral | 2mg/kg (2mg/kg) | | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. |
| dog | LDLo | oral | 1gm/kg (1000mg/kg) | | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. |
| guinea pig | LDLo | intraarterial | 1200ug/kg (1.2mg/kg) | | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. |
| guinea pig | LDLo | intravenous | 1mg/kg (1mg/kg) | | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. |
| human | LDLo | oral | 500ug/kg (0.5mg/kg) | | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. |
| mouse | LD50 | oral | 930ug/kg (0.93mg/kg) | | Journal of Toxicology, Clinical Toxicology. Vol. 22, Pg. 425, 1984. |
| mouse | LD50 | unreported | 900ug/kg (0.9mg/kg) | | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 207, Pg. 688, 1949. |
| mouse | LDLo | intravenous | 600ug/kg (0.6mg/kg) | behavioral: convulsions or effect on seizure threshold | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970. |
| mouse | LDLo | subcutaneous | 2mg/kg (2mg/kg) | behavioral: convulsions or effect on seizure threshold | Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 458, 1967. |
| pig | LDLo | oral | 20ug/kg (0.02mg/kg) | | Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977. |
| rabbit | LD50 | intravenous | 250ug/kg (0.25mg/kg) | behavioral: convulsions or effect on seizure threshold | Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 1, 1958. |
| rat | LD50 | oral | 16200ug/kg (16.2mg/kg) | | Drugs in Japan Vol. 6, Pg. 377, 1982. |
| rat | LDLo | intravenous | 600ug/kg (0.6mg/kg) | behavioral: convulsions or effect on seizure threshold | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970. |
| rat | LDLo | subcutaneous | 3mg/kg (3mg/kg) | behavioral: convulsions or effect on seizure threshold | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 187, Pg. 607, 1937 |
Safety Profile
Hazard Codes: T+ .gif){kind=small}
Risk Statements : 26/27/28
26/27/28: Strychnine mononitrate (66-32-0) is very Toxic by inhalation, in contact with skin and if swallowed
Safety Statements : 22-36/37/39-45
22: Do not breathe dust
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39:When Strychnine mononitrate (66-32-0) used,wear suitable protective clothing, gloves and eye/face protection
RIDADR : UN 1692 6.1/PG 1
WGK Germany: 3
RTECS : WL2450000
HazardClass: 6.1(a).