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Salicylhydroxamic acid

  • Name Salicylhydroxamic acid
  • EINECS201-934-3
  • CAS No. 89-73-6
  • Density1.402g/cm3
  • PSA69.56000
  • LogP0.90210
  • Solubilitysoluble x.
  • Risk CodesR40   
  • Molecular Structure
    Molecular Structure of 89-73-6 (Salicylhydroxamic acid)
  • Hazard Symbols
  • Synonyms
  • Article Data32

Salicylhydroxamic acid Chemical Properties

Molecular Formula: C7H7NO3
Molar mass: 153.14 g/mol
EINECS: 201-934-3
Density: 1.402 g/cm3
Flash Point: 248.9 °C
Index of Refraction: 1.626
Boiling Point: 389.7 °C at 760 mmHg
Vapour Pressure: 9.01E-07 mmHg at 25°C
Melting point: 177 °C (dec.)(lit.)
Appearance: Off-white powder
Product categories of Salicylhydroxamic acid (89-73-6): Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Hydroxylamines
Structure of Salicylhydroxamic acid (89-73-6):
       
XLogP3-AA: 0.9
H-Bond Donor: 3
H-Bond Acceptor: 3
Systematic Name: 2-Hydroxybenzenecarbohydroxamic acid 
SMILES: O=C(c1ccccc1O)NO 
InChI: InChI=1/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10) 
InChIKey: HBROZNQEVUILML-UHFFFAOYAX 
Std. InChI: InChI=1S/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10) 
Std. InChIKey: HBROZNQEVUILML-UHFFFAOYSA-N

Salicylhydroxamic acid Uses

 Salicylhydroxamic acid (89-73-6) can be used for pharmaceutical intermediate.It also can be used as hemical analysis reagents of bismuth, copper, nickel and copper.

Salicylhydroxamic acid Production

 Salicylhydroxamic acid (89-73-6) cand be derived from the o-Hydroxybenzoate sodium hydroxide and Hydrochloric acid in the presence of Hydroxylamine condensation by acidification .

Salicylhydroxamic acid Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 860mg/kg (860mg/kg)   National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat LD50 intraperitoneal 600ug/kg (0.6mg/kg)   Toxicology Letters. Vol. (Suppl), Pg. 247, 1992.
rat LD50 oral 5gm/kg (5000mg/kg)   Toxicology Letters. Vol. (Suppl), Pg. 247, 1992.

Salicylhydroxamic acid Consensus Reports

EPA Genetic Toxicology Program.

Salicylhydroxamic acid Safety Profile

Moderately toxic by intraperitoneal route. Mutation data reported. Used as a pharmaceutical and veterinary drug. When heated to decomposition it emits toxic fumes of NOx.
 

Hazard Codes: Xn
Risk Statements:
20:  Harmful by inhalation
21:  Harmful in contact with skin
22:  Harmful if swallowed 
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
40:  Limited evidence of a carcinogenic effect
Safety Statements:
22:  Do not breathe dust
24:  Avoid contact with skin
25:  Avoid contact with eyes
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing

Salicylhydroxamic acid Specification

 Salicylhydroxamic acid (89-73-6) also can be called SHAM ; Salicylhydroxamate ; Saliaylhydroxamic acid ; 2-Hydroxybenzohydroxamic acid and Benzamide, N,2-dihydroxy- .

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