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Sterigmatocystin

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Name

Sterigmatocystin

EINECS 233-158-6
CAS No. 10048-13-2 Density 1.51 g/cm3
PSA 78.13000 LogP 3.00640
Solubility N/A Melting Point 249-251℃
Formula C18H12O6 Boiling Point 569.7 °C at 760 mmHg
Molecular Weight 324.29 Flash Point 215.9 °C
Transport Information UN 3462 6.1/PG 3 Appearance yellow needles or powder
Safety 36/37-45 Risk Codes 25-40
Molecular Structure Molecular Structure of 10048-13-2 (STERIGMATOCYSTIN) Hazard Symbols ToxicT
Synonyms

7H-Furo[3',2':4,5]furo[2,3-c]xanthen-7-one,3a,12c-dihydro-8-hydroxy-6-methoxy- (7CI,8CI);7H-Furo[3',2':4,5]furo[2,3-c]xanthen-7-one,3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR-cis)-;Sterigmatocystin (6CI);NSC201423;NSC 204985;Sterigmatocystine;

 

Sterigmatocystin Chemical Properties

Empirical Formula: C18H12O6
Molecular Weight: 324.2843
EINECS: 233-158-6
Storage temp: 2-8 °C
Appearance: Yellow needles or powder
Form: Powder
Color: Yellow
Index of Refraction: 1.686
Density: 1.51 g/cm3
Flash Point: 215.9 °C
Enthalpy of Vaporization: 88.65 kJ/mol
Boiling Point: 569.7 °C at 760 mmHg
Vapour Pressure: 1.39E-13 mmHg at 25 °C
Structure of Sterigmatocystin (CAS NO.10048-13-2):
                 

Sterigmatocystin Production

  Sterigmatocystin (CAS NO.10048-13-2) is mainly produced by the fungi Aspergillus nidulans and A. versicolor.

Sterigmatocystin Toxicity Data With Reference

1.    

dnr-bcs 10 µg/disc

    MUREAV    Mutation Research. 97 (1982),339.
2.    

dns-hmn:hla 1 µmol/L

    CNREA8    Cancer Research. 38 (1978),2621.
3.    

msc-hmn:emb 100 µg/L

    KIKNAJ    Kokuritsu Idengaku Kenkyusho Nempo. Annual Report of the National Institute of Genetics.(29)(1978),38.
4.    

orl-rat TDLo:175 mg/kg/52W-C:CAR

    FCTXAV    Food and Cosmetics Toxicology. 8 (1970),289.
5.    

skn-rat TDLo:560 mg/kg/70W-I:CAR

    TXAPA9    Toxicology and Applied Pharmacology. 26 (1973),274.
6.    

orl-rat LD50:120 mg/kg

    FCTXAV    Food and Cosmetics Toxicology. 7 (1969),135.
7.    

ipr-rat LD50:65 mg/kg

    FCTXAV    Food and Cosmetics Toxicology. 7 (1969),135.
8.    

orl-mus LD50:800 mg/kg

    MMAPAP    Mycopathologia et Mycologia Applicata. 35 (1968),373.
9.    

orl-mky LD50:32 mg/kg

    BJEPA5    British Journal of Experimental Pathology. 51 (1970),183.

Sterigmatocystin Consensus Reports

IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 10 ,1976,p. 245.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 1 ,1972,p. 175.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Sterigmatocystin Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
 

Hazard Codes of Sterigmatocystin (CAS NO.10048-13-2): ToxicT
Risk Statements: 25-40
R25 :Toxic if swallowed. 
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 36/37-45
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Sterigmatocystin Specification

 Sterigmatocystin ,its cas register number is 10048-13-2. It also can be called 7H-Furo(3',2':4,5)furo(2,3-c)xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy-  ; 7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR,12cS)- and (3aR,12cS)-8-Hydroxy-6-méthoxy-3a,12c-dihydro-7H-furo[3',2':4,5]furo[2,3-c]xanthén-7-one . It is a poison of the type dermatoxin, from the fungi genus Aspergillus, and is a toxic metabolite structurally closely related to the aflatoxins (compare general fact sheet number 2), and consists of a xanthone nucleus attached to a bifuran structure. The occurrence of sterigmatocystin in raw materials and foods has not been reported often. No country has legislation for Sterigmatocystin (CAS NO.10048-13-2). Natural occurrence appears to be infrequent although only a limited number of surveys have been carried out. Its relatively high levels have been formed in bread, cured ham and salami after inoculation with A. versicolor. And, methods for extraction of sterigmatocystin have been commonly based on a mixture of acetonitrile and 4% aqueous potassium chloride.

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