Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Sulfamerazine

Related Products

Hot Products

Name

Sulfamerazine

EINECS 204-866-2
CAS No. 127-79-7 Density 1.439 g/cm3
PSA 106.35000 LogP 2.90300
Solubility 202mg/L(20 oC) Melting Point 234-238 °C
Formula C11H12N4O2S Boiling Point 519.1 °C at 760 mmHg
Molecular Weight 264.308 Flash Point 267.8 °C
Transport Information N/A Appearance White Solid
Safety 26-36/37 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 127-79-7 (Sulfamerazine) Hazard Symbols IrritantXi
Synonyms

4-Amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide;2-Sulfanilamido-4-methylpyrimidine;Sulfamerazine;Sulfanilamide, N1-(4-methyl-2-pyrimidinyl)- (8CI);N1-(4-Methyl-2-pyrimidinyl)sulfanilamide;Methylsulfazine;Kelamerazine;2-(Sulfanilamido)-4-methylpyrimidine;2-(4-Aminobenzenesulfonamido)-4-methylpyrimidine;(p-Aminobenzolsulfonyl)-2-amino-4-methylpyrimidin;

Article Data 35

Sulfamerazine Consensus Reports

Reported in EPA TSCA Inventory.

Sulfamerazine Specification

The Benzenesulfonamide,4-amino-N-(4-methyl-2-pyrimidinyl)-, with the CAS registry number 127-79-7, is also known as 2-(4-Aminobenzenesulfonamido)-4-methylpyrimidine. It belongs to the product categories of Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds. Its EINECS number is 204-866-2. This chemical's molecular formula is C11H12N4O2S and molecular weight is 264.30. What's more, its systematic name is 4-amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide. Its classification codes are: (1)Anti-infective agents; (2)Antibacterial; (3)Drug / Therapeutic Agent; (4)Reproductive Effect. It is a sulfanilamide that is used as an antibacterial agent. 

Physical properties of Benzenesulfonamide,4-amino-N-(4-methyl-2-pyrimidinyl)- are: (1)ACD/LogP: 0.34; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.34; (4)ACD/LogD (pH 7.4): -0.01; (5)ACD/BCF (pH 5.5): 1.06; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 36.04; (8)ACD/KOC (pH 7.4): 16.4; (9)#H bond acceptors: 6; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 74.78 Å2; (13)Index of Refraction: 1.66; (14)Molar Refractivity: 67.76 cm3; (15)Molar Volume: 183.5 cm3; (16)Polarizability: 26.86×10-24cm3; (17)Surface Tension: 76.4 dyne/cm; (18)Density: 1.439 g/cm3; (19)Flash Point: 267.8 °C; (20)Enthalpy of Vaporization: 79.18 kJ/mol; (21)Boiling Point: 519.1 °C at 760 mmHg; (22)Vapour Pressure: 7.03E-11 mmHg at 25°C.

Uses of Benzenesulfonamide,4-amino-N-(4-methyl-2-pyrimidinyl)-: it can be used to produce N-(4-methyl-pyrimidin-2-yl)-4-(3-oxo-1-thia-4-aza-spiro[4.4]non-4-yl)-benzenesulfonamide by heating. It will need solvent pyridine with the reaction time of 2 hours. The yield is about 78%.

Benzenesulfonamide,4-amino-N-(4-methyl-2-pyrimidinyl)- can be used to produce N-(4-methyl-pyrimidin-2-yl)-4-(3-oxo-1-thia-4-aza-spiro[4.4]non-4-yl)-benzenesulfonamide by heating

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing and gloves.

You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(Nc1nc(ccn1)C)c2ccc(N)cc2
(2)Std. InChI: InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
(3)Std. InChIKey: QPPBRPIAZZHUNT-UHFFFAOYSA-N

The toxicity data is as follows:  

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1400mg/kg (1400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.
mouse LD50 oral 25gm/kg (25000mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 338, 1953.
mouse LD50 subcutaneous 1190mg/kg (1190mg/kg)   Acta Biologica et Medica Germanica. Vol. 27, Pg. 141, 1971.
rat LD50 intravenous 1100mg/kg (1100mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat LD50 subcutaneous 1890mg/kg (1890mg/kg)   Acta Biologica et Medica Germanica. Vol. 27, Pg. 141, 1971.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 127-79-7