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TOCAINIDE

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TOCAINIDE

EINECS 255-505-0
CAS No. 41708-72-9 Density 1.0529 (rough estimate)
PSA 55.12000 LogP 2.36240
Solubility N/A Melting Point 246-266 °C
Formula C11H16 N2 O Boiling Point 328.25°C (rough estimate)
Molecular Weight 192.261 Flash Point N/A
Transport Information N/A Appearance N/A
Safety Human and experimental poison by ingestion. Human systemic effects by ingestion: mental disturbances, coma, cardiac damage, nausea or vomiting, and aplastic anemia. When heated to decomposition it emits toxic fumes of NOx. Risk Codes R22   
Molecular Structure Molecular Structure of 41708-72-9 (TOCAINIDE) Hazard Symbols
Synonyms

(RS)-Tocainide;(?à)-Tocainide;2-Amino-2',6'-propionoxylidide; Astra W 36095; DL-Tocainide; Racemic tocainide;Tocainide; W 36095

Article Data 5

TOCAINIDE Chemical Properties

Product Name: Tocainide (CAS NO.41708-72-9)


Molecular Formula: C11H16N2O
Molecular Weight: 192.26g/mol
Mol File: 41708-72-9.mol
Einecs: 5-505-0
Boiling point: 330.1 °C at 760 mmHg
Flash Point: 153.5 °C
Density: 1.094 g/cm3
Surface Tension: 44 dyne/cm
Enthalpy of Vaporization: 57.27 kJ/mol
Vapour Pressure: 0.00017 mmHg at 25°C
XLogP3: 0.8
H-Bond Donor: 2
H-Bond Acceptor: 2
Product Categories: Active Pharmaceutical Ingredients

TOCAINIDE Uses

Tocainide (CAS NO.41708-72-9) is a class Ib antiarrhythmic agent.

TOCAINIDE Toxicity Data With Reference

1.    

orl-hmn TDLo:5714 µg/kg:CNS,GIT

    DRFUD4    Drugs of the Future. 2 (1977),141.
2.    

orl-man TDLo:2606 mg/kg/11W-I:BLD

    NEJMAG    New England Journal of Medicine. 314 (1986),583.
3.    

orl-man LDLo:229 mg/kg:CNS,CVS

    BMJOAE    British Medical Journal. 288 (1984),760.
4.    

orl-mus LD50:529 mg/kg

    DRFUD4    Drugs of the Future. 2 (1977),141.
5.    

orl-mus LD50:94 mg/kg

    JMCMAR    Journal of Medicinal Chemistry. 24 (1981),1059.

TOCAINIDE Safety Profile

Human and experimental poison by ingestion. Human systemic effects by ingestion: mental disturbances, coma, cardiac damage, nausea or vomiting, and aplastic anemia. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Tocainide (CAS NO.41708-72-9):
Hazard Codes: Xn
Risk Statements: 22 
22:  Harmful if swallowed

TOCAINIDE Specification

 Tocainide ,its CAS NO. is 41708-72-9. is a lidocaine analog, that does not have significant 1st pass metabolism. It is found in two enantiomers. The R isomer is 4x as potent as the S. Oral bioavaliability is 0.9-1.0. In the blood tocainide is 10-20% protein bound. The Volume of distribution is 2.5-3.5 L/kg. 30-50% is excreted unchanged in the urine. The more active R-isomer is cleared faster in anephric patients or those with severe renal dysfunction. The main metabolite is the glucuronidated tocainide carbamic acid. The glucuronosyl transferase is apparently induced by rifampin. Weak inhibition of Cyp1A2 leads to a mild theophylline interaction.
 The synonyms of Tocainide is 2-Amino-2',6'-propionoxylidide ; 2-Amino-n-(2,6-dimethylphenyl)-propanamid ; 6'-Propionoxylidide, 2-amino-2 ; Alanyl-2,6-xylidide ; Astra W-36095 ; W-36095 .

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