This term refers to the addition of an alkyl group (amidoalkyl group) to the alpha (α) carbon of the amide functional group in the bicyclic lactam. This modification can lead to the formation of new stereocenters in the molecule.
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(1'R,6S)-(+)-1-(2'-hydroxy-1'-phenyl-ethyl)-6-propyl-piperidin-2-one
benzyl 2-(5-oxo-2,5-dihydro-2-furanyl-1-pyrrolidinecarboxylate)
