Activate the carboxylic acid group of the crown ether aminocarboxylic acid monomer. This can be done using coupling reagents such as DCC (dicyclohexylcarbodiimide) or HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate) along with a suitable base.
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