The carboxylic acid group of D-glucuronic acid is activated using a coupling reagent like DCC (dicyclohexylcarbodiimide) and a catalyst like DMAP (4-dimethylaminopyridine). This step allows for the conjugation of retinamide to the activated glucuronic acid.
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methyl (4-retinamidophenyl tri-O-acetyl-β-D-glucopyranosid)uronate
(R)-3-{3-[(R)-2-Methoxycarbonyl-1-((S)-toluene-4-sulfinylamino)-ethyl]-phenyl}-3-((S)-toluene-4-sulfinylamino)-propionic acid methyl ester
