In this context, an axially chiral guanidine base is a specific type of catalyst used in the reaction. Guanidine is a chemical compound that can act as a base, and when it is axially chiral, it has a chiral axis in its structure, which imparts chirality to the reaction. Chirality is crucial for achieving asymmetric reactions because it leads to the formation of enantiomerically enriched products.
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(R)-3-bromo-5-((R)-hydroxy(phenyl)methyl)furan-2(5H)-one
