Metalloporphyrins can bind to DNA through intercalation, where they insert themselves between DNA base pairs, or by groove binding, where they interact with the DNA grooves (major or minor grooves). The binding mode can affect the specificity and strength of the interaction.
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1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
[4-((R)-sec-Butoxy)-3-methoxy-phenyl]-acetic acid
(2-fluorophenyl)phenylbromomethane
