The fused tetrazole is combined with a terminal alkyne in the presence of a copper catalyst. The regioselective and stereospecific cycloaddition reaction occurs, resulting in the formation of a 1,2,3-triazole, now containing the N-heterocyclic fused tetrazole moiety.
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5'-O-(di(4-methoxyphenyl)(phenyl)methyl)-2'-O-(1-pentyn-5-yl)-6-N-benzoyladenosine-3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)
1,3,5-tris(2-chloroethoxy)benzene
