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Chemical Baike

Copper-Catalyzed N-Arylation

Combine the arylhydrazones with the copper catalyst and the chosen base in the solvent of choice. Heat the reaction mixture in a microwave reactor. Microwaves can rapidly increase the reaction temperature and promote the formation of N-arylated products. The copper catalyst plays a crucial role in facilitating the N-arylation step by promoting the coupling of the aryl group with the hydrazone nitrogen.

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