The copper-catalyzed transformation involves the reaction of the α-diazoester with a copper catalyst to generate the desired 2,4-disubstituted allenoates. Copper catalysts are often chosen due to their ability to activate diazo compounds and facilitate the generation of reactive intermediates.
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methyl 7-chloro-2-phenylhepta-2,3-dienoate
2-(1-(4-(3,4-dichlorophenyl)piperazin-1-yl)ethyl)-1H-indole
