In some cases, fluorine atoms can be directly introduced into heterocyclic compounds. This can be done by reacting the heterocycle with elemental fluorine (F2), which is a highly reactive and dangerous reagent. Alternatively, you can use safer fluorinating reagents like Selectfluor (F-TEDA-BF4) or Deoxo-Fluor, which are milder and more selective in introducing fluorine atoms.
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Isoxazole, 5-methyl-3-(trifluoromethyl)- (9CI)
UREA
THIOUREA
4-(4'-nitro)phenyl-2H-benzopyran
Cyclohexane, 1,1'-(difluoromethylene)bis[1,2,2,3,3,4,4,5,5,6,6-undecafluoro-
