Electrophilic Carbonyl Carbon

The carbon atom in a carbonyl group (C=O) that is electron-deficient and susceptible to nucleophilic attack.

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Synthesis Regioselectivity Yield Catalyst Steric hindrance Deprotonation Tetrahydrofuran (THF) Anhydrous conditions Leaving group Conjugation Nucleophilic Attack Solvent Effects Base-Catalyzed Hydrolysis Ring-Opening Reaction Activation Energy Spectroscopic Characterization Reaction Optimization Kinetic Isotope Effect (KIE) Stoichiometry Byproduct Formation Isotope Labeling Leaving Group Ability Ester Hydrolysis In situ formation Transition state Rate-determining step reactive intermediate Acyl chlorides Allylic Substitution carbanion Zinc selenolates Selenoesters Resonance stabilization pH dependence Workup procedure Spectroscopic Monitoring Reaction coordinate diagram

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