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Chemical Baike

Formation of the Piperidine Ring

You can start by forming the piperidine ring through a cyclization reaction. One way to do this is by using reductive amination with an amine as the nucleophile and a reducing agent like sodium borohydride. Ensure that the substitution pattern on the piperidine ring corresponds to the desired 2,6-disubstituted pattern.

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Articles of Formation of the Piperidine Ring

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