In Vitro Evaluation

Synthesis Elemental analysis Fluorination Column chromatography Ligands Chemical shift Thin-layer chromatography (TLC) Chlorination Nucleophilic substitution HCl salt IC50 1H NMR spectra Analogues Data Analysis Structure-Activity Relationship (SAR) Analysis Purification and characterization Chemical Synthesis Clinical Trials Literature Review Safety and Toxicity Assessment Publication and Patenting Regulatory Considerations Design Molecular Design Selectivity Testing In Vivo Evaluation Toxicity Assessment Structure Optimization Formulation Development Pharmacokinetics and Toxicology Structure-Activity Relationship (SAR) Pharmacokinetics Toxicity and Safety Assessment Clinical Trials (if applicable) Antiviral Activity PET Imaging Publication and Reporting Pharmacokinetics and Pharmacodynamics Optimization and Iteration Publication and Further Development Radiolabeling Bioavailability and Formulation Formulation and Preclinical Studies Optimization and Lead Compound Selection Toxicology and Safety Assessment Pharmacological Testing Experimental Design Protease inhibitors Radiolabeled σ receptors