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Introduction of the 6-methyl group

To introduce the 6-methyl group, you can use a suitable alkylating agent. This could involve reacting your intermediate compound with a methylating agent under appropriate conditions.

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Articles of Introduction of the 6-methyl group

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Biological testing Purification and characterization Scale-up and optimization Purification and Isolation Start with appropriate starting materials Formation of the pyrimidine-2(1H)-thione ring Introduction of the 4-trifluoromethyl group Resolution of the compound to obtain (S)-(-)-1,4-diaryl-6-methyl-4-trifluoromethyl-3,4-dihydropyrimidine-2(1H)-thiones Introduction of the aryl groups Synthesis of the Pyrrolo[2,3-d]pyrimidine Ring Introduction of the 2-Amino and 4-Oxo Functionalities Introduction of the 5-Substituent Functional Group Protection and Deprotection Thymidylate Synthase Inhibition Assay