The hydroxy group can be introduced using a variety of methods, such as a nucleophilic substitution reaction or a selective oxidation. One common method is using a nucleophilic substitution reaction with a hydroxide source. For example, you can use sodium hydroxide or sodium ethoxide in a solvent like ethanol to replace a leaving group (e.g., a halide) with a hydroxyl group at the desired position.
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5-hydroxy-2-[3-(4-methoxyphenyl)-1,2,3,4-tetrahydronaphth-2-yl]chromone
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9-oxabicyclo[4.2.1]nona-2,4-diene
