The Knoevenagel reaction is typically initiated by the condensation of an aldehyde or ketone (A) with an active methylene compound (B), such as malononitrile, ethyl cyanoacetate, or a similar compound. The reaction is catalyzed by a base, often sodium ethoxide or sodium methoxide. The reaction proceeds to form an α,β-unsaturated compound, often a conjugated enone.
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2-amino-5-oxo-4-(1-phenylethyl)-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile
1,5-dihydro-5-(4-nitrophenyl)-2H-pyrano[2,3-d]pyrimidine-2,4(3H)-dione
2-phenyl-2,3,4,5-tetrahydro-1,4-benzoxazepine
2-<2-(4-formylphenyl)ethenyl>pyridine
(2S)-2-[(R)-hydroxy(4-phenylphenyl)methyl]cyclopentanone
2,2-Oxiranedicarbonitrile, 3-(4-methylphenyl)-
