The addition of a Lewis acid, such as a metal halide or Lewis acid salt (e.g., TiCl4), in conjunction with the RCM catalyst, can enhance the reaction's efficiency. The Lewis acid can coordinate with the amine functionality in the substrate, which helps control the stereochemistry of the reaction. This is particularly important in the synthesis of enantiopure compounds, as it aids in achieving high levels of stereocontrol.
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(S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate
C29H53FeNOP2
