The Mannich reaction involves the addition of an amine to a carbonyl compound, typically an aldehyde or ketone. This results in the formation of a β-amino carbonyl compound. In the tandem reaction, the enolate generated from the aldol step can serve as a nucleophile in the Mannich-type reaction.
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3-Hydroxy-2-methyl-3-naphthalen-2-yl-1-phenyl-propan-1-one
(4R,trans)-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanol
