Palladium-catalyzed C-H activation reactions can be used for intermolecular carbenoid insertion into C-H bonds. While not typically highly selective for primary C-H bonds, ligand design and reaction conditions can be optimized for improved selectivity. Palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura or Negishi reactions, can lead to enantioselective C-C bond formation when chiral ligands are employed.
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