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Penicillanic Acid Analogues

Penicillanic acid is a key structural component found in natural penicillins. The γ-lactam analogues of penicillanic acid are designed to retain the core structure while introducing modifications to enhance stability or activity. These modifications can include alterations in the side chains or the introduction of different functional groups to improve resistance to bacterial β-lactamases, enzymes produced by bacteria that can break down β-lactam antibiotics.

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