Now, you can perform the Reformatsky reaction by adding the prepared ethylbromodifluoroacetate to the imine. The reaction mixture typically includes zinc metal and a suitable source of protons (e.g., water or an alcohol) to facilitate the formation of the enolate. The zinc enolate will react with the imine to form the gem-difluoro-β-aminoesters or gem-difluoro-β-lactams.
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methyl 1-(1-bromocyclobutylcarbonyl)cyclohexanecarboxylate
methyl 1-(cyclobutylcarbonyl)cyclohexanecarboxylate
Benzenamine, 4-methoxy-N-(phenylmethylene)-, (E)-
