The site selectivity of the reaction refers to which carbon atom of the dipolarophile (methoxyallene) reacts with the 1,3-dipole (nitrone). Lewis acids can coordinate with the dipolarophile, directing the reaction to occur at a specific carbon atom. This coordination typically occurs at the most electron-rich site on the dipolarophile.
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(3S,4Z)-2-benzyl-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-(methoxymethylene)isoxazolidine
