a. Dissolve the N-acetylated amino acid obtained from step 1 in anhydrous DCM. b. Add an equimolar amount of tert-butylamine to the solution. This will protect the carboxyl group as a tert-butyl amide. c. Stir the reaction mixture at room temperature for several hours (typically overnight). d. Quench the reaction with a diluted hydrochloric acid solution. e. Extract the product with DCM and wash the organic phase with water. f. Dry the organic phase over anhydrous sodium sulfate and concentrate the solution under reduced pressure to obtain the N-acetyl, tert-butyl amide derivative of the amino acid.
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C20H31N3O4
4H-1-Benzothiopyran-4-one, 2,3-dihydro-2,2,6-trimethyl-
