This indicates that the reaction is carried out without the use of transition metal catalysts. Many traditional cross-coupling reactions involve transition metals like palladium, but there is a growing interest in developing transition-metal-free methods due to cost, toxicity, and sustainability concerns.
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1-(2-iodobenzyl)-1H-indole
Benzothiazole, 6-methoxy-2-phenyl-
1-benzyl-4-isobutylpiperazine-2,3-dione
