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Name Trandolapril
EINECS618-046-0
CAS No. 87679-37-6
Density1.181 g/cm³
PSA95.94000
LogP3.10210
SolubilityInsoluble in water
Melting Point122-123 °C
FormulaC₂₄H₃₄N₂O₅
Boiling Point626 °C at 760 mmHg
Molecular Weight430.544
Flash Point332.4 °C
Transport InformationN/A
Appearancewhite powder
Safety
Risk CodesN/A
Molecular Structure
Hazard SymbolsN/A
SynonymsN/A
Article Data11

Trandolapril Chemical Properties

Molecular Formula: C₂₄H₃₄N₂O₅
Molecular Weight: 430.54 g/mol
Protein binding: Trandolapril 80%,(independent of concentration);Trandolaprilat 65 to 94%,(concentration-dependent)
Half life: 6 hours (trandolapril),10 hours (trandolaprilat)
Metabolism: Hepatic
Storage temp.: Room temp
Excretion: Fecal and renal
Index of Refraction: 1.549
Surface Tension: 48.7 dyne/cm
Density: 1.181 g/cm³
Flash Point: 332.4 °C
Appearance: White powder
Solubility in water: Insoluble
Enthalpy of Vaporization: 97.42 kJ/mol
Boiling Point: 626 °C at 760 mmHg
Vapour Pressure of Trandolapril (CAS NO.87679-37-6): 1.55E-16 mmHg at 25 °C
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Following is the structure of Trandolapril (CAS NO.87679-37-6):

Trandolapril Uses

Trandolapril (CAS NO.87679-37-6) is used to treat high blood pressure, and it can also be used to treat other conditions. Trandolapril is a prodrug deesterified to trandolaprilat. It is believed that it exerts its antihypertensive effect through the renin-angiotensin-aldosterone system.

Trandolapril Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	oral	2gm/kg (2000mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse	LD50	intraperitoneal	1285mg/kg (1285mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse	LD50	intravenous	3gm/kg (3000mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
mouse	LD50	oral	3990mg/kg (3990mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat	LD50	intraperitoneal	1420mg/kg (1420mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat	LD50	intravenous	> 2gm/kg (2000mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.
rat	LD50	oral	> 5gm/kg (5000mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.

Trandolapril Consensus Reports

Trandolapril (CAS NO.87679-37-6) acts by competitive inhibition of Angiotensin Converting Enzyme (ACE), a key enzyme in the renin-angiotensin system (RAS pathway) ,it plays a very important role in regulating blood pressure.

Trandolapril Safety Profile

RTECS: NL6015178
Some side effects are reported for Trandolapril (CAS NO.87679-37-6) include nausea, vomiting, or diarrhea; headache; dry cough; dizziness or lightheadedness when sitting up or standing; hypotension or fatigue.

Trandolapril Specification

Trandolapril with a CAS number of 87679-37-6, also named (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid , is an ACE inhibitor. Trandolapril's possible drug interactions: Patients on diuretics maybe will experience an excessive reduction of blood pressure after initiation of therapy with Trandolapril. Trandolapril (CAS NO.87679-37-6) can reduce potassium loss caused by thiazide diuretics, and increase serum potassium when used alone. So hyperkalemia is a possible risk. Increased serum lithum levels can occur in patients who are also on lithium.It should be stored in original container in a cool dark place.

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