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Name	Triamterene	EINECS	206-904-3
CAS No.	396-01-0	Density	1.502 g/cm³
PSA	129.62000	LogP	2.57700
Solubility	<0.1 g/100 mL at 20 °C in water	Melting Point	316 °C
Formula	C₁₂H₁₁N₇	Boiling Point	573.4 °C at 760 mmHg
Molecular Weight	253.266	Flash Point	335.5 °C
Transport Information	UN 2811	Appearance	Yellow solid
Safety	26-36/37/39-45-33-24-16-7	Risk Codes	22-36/37/38-36/38-23/25
Molecular Structure		Hazard Symbols	Xn, T, F
Synonyms	Pteridine,2,4,7-triamino-6-phenyl- (8CI);2,4,7-Triamino-6-phenylpteridine;6-Phenyl-2,4,7-triaminopteridine;Ademin;Ademine;Diren;Ditak;Diurene;Dyren;Dyrenium;Dytac;Jatropur;NSC 77625;Noridil;Pterofen;Pterophene;SKF8542;Taturil;Teriam;Teridin;Tri-Span;Triampur;Triamteren;Triteren;Urocaudal;	Article Data	16

Triamterene Chemical Properties

CBNumber: CB0663775
Chemical Name: 2,4,7-Triamino-6-phenylpteridine
Molecular Formula: C12H11N7
Formula Weight: 253.26
CAS No: 396-01-0
Synonyms:6-PHENYL-PTERIDINE-2,4,7-TRIAMINE;6-PHENYL-2,4,7-PTERIDINETRIAMINE;6-PHENYL-2,4,7-TRIAMINO PTERIDINE;ADEMINE;2,4,7-TRIAMINO-6-PHENYLPTERIDINE;TRIAMTERENE;2,4,7-triamino-6-fenilpteridina;2,4,7-triamino-6-phenyl-pteridin
molecular structure:

mp :316°C
Fp :11 °C
storage temp:2-8°C

2,4,7-Triamino-6-phenylpteridine relates to pharmaceutical preparations with cardiac, particularly anti-arrhythmic activity. These preparations comprise, as an active principle, at least one compound of formula I: ##STR1## where R represents a lipophilic radical. The pharmaceutical compositions may comprise 2,4,7-Triamino-6-phenylpteridine in the presence of other pharmaceutical excipients and adjuvants.

Triamterene Toxicity Data With Reference

1.	otr-ham:emb 25 mg/L	ENMUDM Environmental Mutagenesis. 8 (Suppl 6)(1986),4.
2.	cyt-ham:lng 2800 µg/L	GMCRDC Gann Monograph on Cancer Research. 27 (1981),95.
3.	orl-wmn TDLo:42 mg/kg/3W-I:SYS	MJAUAJ Medical Journal of Australia. 147 (1987),262.
4.	orl-rat LD50:400 mg/kg	YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775.
5.	ipr-rat LD50:200 mg/kg	YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 21 (1979),775.
6.	orl-mus LD50:285 mg/kg	FRXXBL French Demande Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #2314719 .
7.	ipr-mus LD50:249 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),519.
8.	scu-mus LD50:620 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),519.

Triamterene Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: body temperature increase, hepatitis. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.
Harmful if swallowed
Do not breathe dust
Wear suitable protective clothing and gloves

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