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Cas Database |
| Name |
Trimethadione |
EINECS | N/A |
| CAS No. | 127-48-0 | Density | 1.171g/cm3 |
| PSA | 46.61000 | LogP | 0.31150 |
| Solubility | Soluble in water 50 g/L. | Melting Point |
45-46°C |
| Formula | C6H9 N O3 | Boiling Point | 78-80°C 5mm |
| Molecular Weight | 143.142 | Flash Point | 48°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Human poison by unspecified routes. Moderately toxic experimentally by ingestion, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. Human reproductive effects by ingestion: effects on newborn, including physical and other postnatal measures or effects. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial, musculoskeletal, cardiovascular, and urogenital systems. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also KETONES. | Risk Codes | 61-20/21/22 |
| Molecular Structure |
|
Hazard Symbols | May have adverse side effects; toxic in overdose. |
| Synonyms |
3,3,5-Trimethyl-2,4-diketooxazolidine;3,5,5-Trimethyl-2,4-oxazolidinedione; Absentol; Edion; Epidione; Epixal;Minoaleviatin; NSC 15799; NSC 169503; Petidion; Petidon; Petilep; Pitmal;Ptimal; Tridion; Tridione; Tridone; Trimedal; Trimetadione; Trimethadion;Trimethadione; Trimethin; Trimetin; Trioxanona; Troxidone |
Article Data | 14 |
Trimethadione Chemical Properties
The IUPAC name of Trimethadione (CAS NO.127-48-0): 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione
Synonyms: 2,4-Oxazolidinedione, 3,5,5-trimethyl- ; 3,3,5-Trimethyl-2,4-diketooxazolidine ; 3,5,5-Trimethyl-2,4-oxazolidinedione ; 3,5,5-Trojmetylooksazolidyno-2,4-dion ; 3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish] ; 4-27-00-03237 (Beilstein Handbook Reference) ; Absentol ; Absetil ; Convenixa ; Convexina ; Edion ; Epidione ; Epixal ; Minoaleviatin ; Petidion ; Petidon ; Tioxanona ; Tridilona ; Trimethin ; Trimethinum ; Trimetin ; Trioksal ; Trioxanona
CAS: 127-48-0
EINECS: 204-845-8
Molecular Formula: C6H9NO3
Formula Weight: 143.14 g/mol
Molecular Structure:
.png)
Index of Refraction: 1.408
Density: 0.724 g/cm3
Melting point: 45-46°C
Flash Point: 32.8 °C
Boiling Point: 147.3 °C at 760 mmHg
Trimethadione Toxicity Data With Reference
The toxicity of Trimethadione (CAS NO.127-48-0):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intraperitoneal | 2gm/kg (2000mg/kg) | BEHAVIORAL: SLEEP | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. |
| man | LDLo | unreported | 88mg/kg (88mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
| mouse | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 60, 1961. | |
| mouse | LD50 | intravenous | 2gm/kg (2000mg/kg) | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. | |
| mouse | LD50 | oral | 2100mg/kg (2100mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 377, 1973. | |
| mouse | LD50 | subcutaneous | > 1gm/kg (1000mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 11, Pg. 141, 1956. | |
| mouse | LD50 | unreported | 2170mg/kg (2170mg/kg) | United States Patent Document. Vol. #4056540, | |
| rabbit | LD50 | intraperitoneal | 1500mg/kg (1500mg/kg) | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. | |
| rabbit | LD50 | intravenous | 1500mg/kg (1500mg/kg) | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 1330, 1946. | |
| rat | LD50 | intraperitoneal | 280mg/kg (280mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
| rat | LD50 | intravenous | 160mg/kg (160mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. | |
| rat | LD50 | oral | 2140mg/kg (2140mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 138, Pg. 224, 1962. | |
| rat | LD50 | subcutaneous | 2gm/kg (2000mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 312, 1972. |
Trimethadione Safety Profile
The Hazard Codes of Trimethadione (CAS NO.127-48-0):
T
Risk Statements: R61:May cause harm to the unborn child. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: S53:Avoid exposure - obtain special instructions before use. S22:Do not breathe dust. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: RQ2100000
Human poison by unspecified routes. Moderately toxic experimentally by ingestion, subcutaneous, intraperitoneal, and intravenous routes. An experimental teratogen. Human reproductive effects by ingestion: effects on newborn, including physical and other postnatal measures or effects. Human teratogenic effects by ingestion: developmental abnormalities of the craniofacial, musculoskeletal, cardiovascular, and urogenital systems. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also KETONES.
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