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Basic Information
CAS No.: 1330-78-5
Name: Tritolyl phosphate
Molecular Structure:
Molecular Structure of 1330-78-5 (Tritolyl phosphate)
Formula: C21H21O4P
Molecular Weight: 368.39
Synonyms: Phosphoricacid, tritolyl ester (8CI);Celluflex 179C;Cresyl phosphate;Disflamoll TKP;Durad 124;Durad 125;Fyrquel 150;Imol S 140;Kronitex;Kronitex R;KronitexTCP;Lindol;Lindol XP Plus;Phosphlex 179A;Phosphoric acid tricresyl ester;RB 6;Sansocizer TCP;SumiguardTBT;Syn-O-Ad 8484;T 306 (ester);Tricresol phosphate;
EINECS: 215-548-8
Density: 1.143 g/cm3
Melting Point: - 30 ºC
Boiling Point: 265 ºC (10 mmHg)
Flash Point: >110 ºC
Solubility: INSOLUBLE
Appearance: colorless to pale yellow liquid.
Hazard Symbols: ToxicT,DangerousN
Risk Codes: 39/23/24/25-51/53
Safety: 20/21-28A-45-61
Transport Information: UN 2574
PSA: 163.71000
LogP: 18.77010
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Chemistry

Molecular formula: C21H21O4P
Molar mass :368.37 g/mole
TRITOLYL PHOSPHATE,often abbreviated TCP,it's Melting point is about -40 °C;Boiling point is 240-255 °C.INSOLUBLE in water.it is colourless viscous liquid when pure, but commercial samples are typically yellow.

Uses

    Tricresyl phosphate can be used as a plasticizer in nitrocellulose, varnishes, acrylate lacquers, and in polyvinyl chloride.
    It is a flame retardant in plastics and rubbers.
    It is used as a gasoline additive as a lead scavenger for tetra-ethyl lead.
    It is a hydraulic fluid and a heat exchange medium. Exploiting its hydrophobic properties, it is used in waterproofing of materials. It is a solvent for extractions, a solvent for nitrocellulose and other polymers.
    It is also used as an AW additive and EP additive in lubricants, and in hydraulic fluids. 
   As a gasoline additive, it helps preventing engine misfires.

Production

TRITOLYL PHOSPHATE is a derived from cresol and phosphoric acid. can be manufactured by reaction of cresols with phosphorus oxychloride:

OPCl3 + 3 HOC6H4CH3 → OP(OC6H4CH3)3 + 3 HCl

Toxicity Data With Reference

1.   

skn-rbt 500 mg open MLD

   UCDS**    Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 12/29 ,1964.
2.   

eye-rbt 500 mg/24H MLD

   28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,207.
3.   

orl-mus TDLo:2250 mg/kg (male 7D pre):TER

   FAATDF    Fundamental and Applied Toxicology. 10 (1988),344.
4.   

orl-wmn TDLo:70 mg/kg/14D:PNS,CNS

   LANCAO    Lancet. 1 (1981),88.
5.   

orl-hmn LDLo:1800 mg/kg

   ARZNAD    Arzneimittel-Forschung. Drug Research. 7 (1957),585.
6.   

orl-rat LD50:5190 mg/kg

   85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,1131.
7.   

orl-rat LD50:5190 mg/kg

   28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,207.
8.   

orl-mus LD50:3900 mg/kg

   85GMAT    Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al.,Moscow, USSR.: Centre of International Projects, GKNT,1982,114.
9.   

orl-dog LDLo:500 mg/kg



RTECS : TD0175000
TRITOLYL PHOSPHATE(TCP) is a known neurotoxin and is of “toxicological importance” and has been responsible for many deaths. The most serious incident arose in the 1920s when it was used as an adulterant for Jamaican ginger.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Moderately toxic by ingestion and skin contact. Human systemic effects by ingestion: flaccid paralysis without anesthesia, motor activity changes, and muscle weakness. An experimental teratogen. Experimental reproductive effects. An eye and skin irritant. Combustible. When heated to decomposition it emits toxic fumes of POx.


Hazard Codes : Xn,N,T
Risk Statements:  21/22-51/53-39/23/24/25
Safety Statements  :28-61-45-28A-20/21
RIDADR : UN 2574 6.1/PG 2

Standards and Recommendations

DOT Classification:  6.1; Label: Poison