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| CAS No.: | 1404-88-2 |
|---|---|
| Name: | Tyrothricin |
| Molecular Structure: | |
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| Formula: | C6H13NO5 |
| Molecular Weight: | 179.17112 |
| Synonyms: | Bactratycin;Coltirot; Dermotricine; Hydrotricine; Intraderm tyrothricin; Martricin;Solutricine; Tyri 10; Tyroderm; Tyrozets |
| Density: | 1.32g/cm3 |
| Boiling Point: | 1516.6°Cat760mmHg |
| Flash Point: | 871°C |
| Safety: | Poison by intraperitoneal and intravenous routes. Mutation data reported. Incompatible with alkalies, strong acids. |
| PSA: | 379.75000 |
| LogP: | 5.10700 |
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Chemistry
Chemistry informtion about Tyrothricin (CAS NO.1404-88-2) is:
IUPAC Name: 3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-Oxoethyl)-9-(3-Aminopropyl)-3,22,25-Tribenzyl-15-[(4-Hydroxyphenyl)Methyl]-6-(2-Methylpropyl)-2,5,8,11,14,18,21,24,27-Nonaoxo-12-Propan-2-Yl-1,4,7,10,13,16,19,23,26-Nonazabicyclo[26.3.0]Hentriacontan-17-Yl]Propanoic Acid
Synonyms: 3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-Amino-2-Oxo-Ethyl)-9-(3-Aminopropyl)-3,22,25-Tribenzyl-15-[(4-Hydroxyphenyl)Methyl]-6-Isobutyl-12-Isopropyl-2,5,8,11,14,18,21,24,27-Nonaoxo-1,4,7,10,13,16,19,23,26-Nonazabicyclo[26.3.0]Hentriacontan-17-Yl]Propanoic Acid
MF: C65H85N11O13
MW: 1228.436300 g/mol
Density: 1.32 g/cm3
Flash Point: 871 °C
Boiling Point: 1516.6 °C at 760 mmHg
Enthalpy of Vaporization: 245.34 kJ/mol
Following is the molecular structure of Tyrothricin (CAS NO.1404-88-2) is:
Uses
Tyrothricin (CAS NO.1404-88-2) can cause the throat, gastric mucosa, and angina. Condition for the application is that the mucous membrane itself is still intact, so there is no contact with the bloodstream and therefore no risk of systemic absorption.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957. | |
| mouse | LD50 | oral | > 3gm/kg (3000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957. | |
| mouse | LD50 | subcutaneous | > 1500mg/kg (1500mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 98, 1957. | |
| mouse | LDLo | intravenous | 1200ug/kg (1.2mg/kg) | behavioral: somnolence (general depressed activity) behavioral: excitement lungs, thorax, or respiration: other changes | Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 75, 1942 |
Safety Profile
Poison by intraperitoneal and intravenous routes. Mutation data reported. Incompatible with alkalies, strong acids.
Safety Statements:
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: YP2975000
Specification
Tyrothricin (CAS NO.1404-88-2) is a cyclic polypeptide-antibiotic mixture from Bacillus brevis. It is a locally effective antibiotic effective against gram-positive bacteria. It is sometimes combined with benzocaine 5mg to provide relief from sore throats. In systemic intake can lead to severe side effects, therefore, the use is limited to topical application. It belongs pharmacologically closely related compounds such as colistin, polymyxin B and bacitracin to the group of polypeptide antibiotics. There are no cross-resistance to these three agents.Known hypersensitivity reactions are common, temporary loss of balance (see Vestibular system) and nephrotoxic effects, ie Impairment of renal function. There are no long term studies about its effect on pregnancy and lactation.