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Vamidothion

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Name

Vamidothion

EINECS 218-894-8
CAS No. 2275-23-2 Density 1.24 g/cm3
PSA 125.04000 LogP 2.37910
Solubility 4,000,000 mg l-1 Melting Point 43oC
Formula C8H18 N O4 P S2 Boiling Point °Cat760mmHg
Molecular Weight 287.341 Flash Point 2 ºC
Transport Information UN 2811 Appearance Colorless needles.
Safety Poison by ingestion and skin contact. Mutation data reported. When heated to decomposition it emits very toxic fumes of POx, SOx, and NOx. Risk Codes R21;R25;R50   
Molecular Structure Molecular Structure of 2275-23-2 (Vamidothion) Hazard Symbols
Synonyms

Phosphorothioicacid, O,O-dimethyl ester, S-ester with 2-[(2-mercaptoethyl)thio]-N-methylpropionamide(7CI,8CI); Dimethyl S-[2-(1-methylcarbamoylethylthio)ethyl] phosphorothiolate;Kilval; O,O-Dimethyl S-[2-(1-methylcarbamoylethylthio)ethyl] phosphorothioate;RP 9895; Vamidoate; Vamidothion; XMC

 

Vamidothion Chemical Properties

Chemistry informtion about N-Methyl-O,O-Dimethylthiolophos-Phoryl-5-Thia-3-Methyl-2-Valeramide (CAS NO.2275-23-2) is:
IUPAC Name: 2-(2-Dimethoxyphosphorylsulfanylethylsulfanyl)-N-Methylpropanamide
Synonyms: Vamidothion ; Vamidothion(Content>10%) ; 10465rp ; 2-(2-Dimethoxyphosphinoylthioethylthio)-N-Methylpropionamide ; Americancyanamid-43073 ; Dimethyls-(2-(1-Methylcarbamoylethylthio)Ethyl)Phosphorothiolate ; Ent26,613 ; N-Methyl-3-Thia-2-Methyl-Valeramiddero,O-Dimethylthiolphosphorsaeure 
MF: C8H18NO4PS2
MW: 287.34
EINECS: 218-894-8 
Density: 1.24 g/cm3
Flash Point: 2 °C
Storage temp.: 0-6°C
Following is the molecular structure of  N-Methyl-O,O-Dimethylthiolophos-Phoryl-5-Thia-3-Methyl-2-Valeramide (CAS NO.2275-23-2) is:

Vamidothion Uses

  N-Methyl-O,O-Dimethylthiolophos-Phoryl-5-Thia-3-Methyl-2-Valeramide (CAS NO.2275-23-2) is a systemic acaricide and insecticide.

Vamidothion Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 35mg/kg (35mg/kg)   Pesticide Manual. Vol. 9, Pg. 856, 1991.
cat LD50 unreported 117mg/kg (117mg/kg)

behavioral: ataxia behavioral: coma kidney, ureter, and bladder: urine volume increased

Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(3), Pg. 107, 1976.
dog LD50 oral 110mg/kg (110mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 530, 1973.
guinea pig LD50 oral 85mg/kg (85mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 530, 1973.
guinea pig LD50 unreported 85mg/kg (85mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 349, 1971.
mouse LD50 oral 40mg/kg (40mg/kg)

behavioral: tremor
behavioral: convulsions or effect on seizure threshold gastrointestinal: changes in structure or function of salivary glands

Meditsinskii Zhurnal Uzbekistana. Vol. (8), Pg. 65, 1972.
mouse LD50 skin 1460mg/kg (1460mg/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 1621, 1986.
mouse LD50 unreported 43mg/kg (43mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 349, 1971.
rabbit LD50 oral 160mg/kg (160mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(2), Pg. 58, 1970.
rabbit LD50 skin 1160mg/kg (1160mg/kg)   World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat LC50 inhalation 1730mg/m3/4H (1730mg/m3)   Pesticide Manual. Vol. 9, Pg. 856, 1991.
rat LD50 oral 64mg/kg (64mg/kg)   "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969Vol. 5, Pg. 233, 1976.
rat LD50 unreported 64mg/kg (64mg/kg)   "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 349, 1971.

Vamidothion Consensus Reports

EPA Genetic Toxicology Program.

Vamidothion Safety Profile

Poison by ingestion and skin contact. Mutation data reported. When heated to decomposition it emits very toxic fumes of POx, SOx, and NOx.
Hazard Codes:
ToxicT
DangerousN
HarmfulXn
FlammableF
Risk Statements:
R21:Harmful in contact with skin. 
R25 :Toxic if swallowed. 
R50:Very toxic to aquatic organisms. 
R36:Irritating to eyes. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R11:Highly flammable.
Safety Statements:
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets. 
S16:Keep away from sources of ignition.
RIDADR: UN 2811
RTECS: TF7900000
HazardClass: 6.1(b)
PackingGroup: III

Vamidothion Specification

 N-Methyl-O,O-Dimethylthiolophos-Phoryl-5-Thia-3-Methyl-2-Valeramide (CAS NO.2275-23-2) is a colorless needles.
First Aid Measures:
Ingestion: Seek medical assistance.
Inhalation: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Skin: Systemic effects can occur from dermal exposure to organophosphates. Remove contaminated clothing, wash skin, hair and nails vigorously with repeated soap washings. Leather absorbs pesticides; all contaminated leather should be discarded. Rescue personnel and bystanders should avoid direct contact with contaminated skin, clothing, or other objects. Treatment should include recommendations listed in the oral exposure section when appropriate.
Eyes: Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Patients symptomatic following exposure should be observed in a controlled setting until all signs and symptoms have fully resolved. Treatment should include recommendations listed in the oral exposure section when appropriate.
Handling and Storage:
Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

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