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Cas Database

Name	Verapamil	EINECS	200-145-1
CAS No.	52-53-9	Density	1.058 g/cm³
PSA	63.95000	LogP	5.09308
Solubility	N/A	Melting Point	25°C
Formula	C₂₇H₃₈N₂O₄	Boiling Point	586.1 °C at 760 mmHg
Molecular Weight	454.61	Flash Point	308.3 °C
Transport Information	N/A	Appearance	Viscous, pale yellow oil.
Safety		Risk Codes	R14; R34; R37
Molecular Structure		Hazard Symbols	C
Synonyms	Valeronitrile,5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-(7CI,8CI);5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;CP 16533-1;Lekoptin;Iproveratril;D 365;R,S-Verapamil;NSC 272306NA;VPL;dl-Verapamil;	Article Data	14

Verapamil Chemical Properties

Synonyms: 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-isopropylpentanenitrile;-2-isopropyl-;2-isopropyl-;4-dimethoxy-alpha-(1-methylethyl)-l)-;5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylv;5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylval;5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;aleronitrile
Molecular Formula: C₂₇H₃₈N₂O₄
Molecular Weight: 454.6

Verapamil History

Verapamil is a class 4 antiarrhythmic, more effective than digoxin in controlling ventricular rate, and was approved by the United States Food and Drug Administration in 1981.

Verapamil Toxicity Data With Reference

1.	ivn-man TDLo:1429 µg/kg/5M-C:CVS,PUL,SKN	NEJMAG New England Journal of Medicine. 306 (1982),238.
2.	orl-wmn TDLo:64 mg/kg	BMJOAE British Medical Journal. 2 (1978),1127.
3.	orl-man TDLo:48 mg/kg/2W-I	NEJMAG New England Journal of Medicine. 306 (1982),612.
4.	orl-man LDLo:83 mg/kg	AJEMEN American Journal of Emergency Medicine. 7 (1989),624.
5.	ivn-man TDLo:1429 µg/kg/5M-C	NEJMAG New England Journal of Medicine. 306 (1982),238.
6.	ivn-man TDLo:71 µg/kg	AHJOA2 American Heart Journal. 111 (1986),622.
7.	ivn-cld TDLo:250 µg/kg/5M-C	AHJOA2 American Heart Journal. 106 (1983),145.
8.	orl-rat LD50:163 mg/kg	EJMCA5 European Journal of Medicinal Chemistry. Chimie Therapeutique. 25 (1990),351.
9.	ipr-rat LD50:67 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 31 (1981),1401.
10.	ivn-rat LD50:7250 µg/kg	PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 22 (1988),123.

Verapamil Consensus Reports

ISOPTIN's consensus:
Cyanide and its compounds are on the Community Right-To-Know List.

Verapamil Safety Profile

ISOPTIN's safety:
A poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NO_x and CN⁻. See also NITRILES.

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