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Yoshi 864

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Name

Yoshi 864

EINECS N/A
CAS No. 3458-22-8 Density g/cm3
PSA 115.53000 LogP 2.66310
Solubility N/A Melting Point 94-95°
Formula C8H19 N O6 S2 . Cl H Boiling Point 510.1°Cat760mmHg
Molecular Weight 325.86 Flash Point 262.3°C
Transport Information N/A Appearance N/A
Safety Poison by intraperitoneal and intravenous routes. Human systemic effects by intravenous route: somnolence, hypermotility, diarrhea, nausea or vomiting. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, SOx, and HCl. Risk Codes N/A
Molecular Structure Molecular Structure of 3458-22-8 (Improsulfan hydrochloride) Hazard Symbols N/A
Synonyms

3,3'-iminodi-1- propanol dimethanesulfonate;864 T;alkylating agent 864;bis(3-mesyloxypropyl)amine;dimesyloxydipropylamine tosylate;improsan;improsan hydrochloride;improsan tosylate;NSC-102627;NSC-140117;yoshi 864

 

Yoshi 864 Chemical Properties

Molecular Formula of Yoshi 864 (CAS NO.3458-22-8): C8H20ClNO6S2
Molecular Weight: 325.8305 g/mol
Structure of Yoshi 864 (CAS NO.3458-22-8):
     
IUPAC Name: 3-(3-Methylsulfonyloxypropylamino)propyl methanesulfonate hydrochloride

Yoshi 864 Toxicity Data With Reference

1.    

oms-hmn:lym 100 mg/L

    EJCAAH    European Journal of Cancer. 14 (1978),741.
2.    

ipr-rat TDLo:3744 mg/kg/52W-I:NEO

    NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-18 ,1978.
3.    

ivn-hmn TDLo:5400 µg/kg/2D-I:CNS,GIT

    CANCAR    Cancer. 35 (1975),1145.
4.    

ivn-rat LD50:75 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 24 (1974),1139.
5.    

ipr-mus LD10:170 mg/kg

    JMCMAR    Journal of Medicinal Chemistry. 20 (1977),515.

Yoshi 864 Consensus Reports

NCI Carcinogenesis Bioassay (ipr); Clear Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-18 ,1978. .

Yoshi 864 Safety Profile

Poison by intraperitoneal and intravenous routes. Human systemic effects by intravenous route: somnolence, hypermotility, diarrhea, nausea or vomiting. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. When heated to decomposition Yoshi 864 (CAS NO.3458-22-8) emits very toxic fumes of NOx, SOx, and HCl.

Yoshi 864 Specification

 Yoshi 864 ,its cas register number is 3458-22-8. It also can be called 1-Propanol, 3,3'-iminodi-, dimethanesulfonate (ester),
hydrochloride ; and Improsulfan hydrochloride .

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