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CAS No.: | 1028307-48-3 |
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Name: | 3-[2-[[(2-Methoxyphenyl)Methyl]aMino]ethyl]-2,4(1H,3 H)-quinazolinedione |
Molecular Structure: | |
Formula: | C18H19N3O3 |
Molecular Weight: | 325.36 |
Synonyms: | 3-{2-[(2-Methoxybenzyl)amino]ethyl}-2,4(1H,3H)-quinazolinedione; 3-[2-[[(2-Methoxyphenyl)methyl]amino]ethyl]-2,4(1H,3H)-quinazolinedione; 3-[2-[[(2-Methoxyphenyl)Methyl]Amino]Ethyl]-2,4(1H,3H)Quinazolinedione |
Density: | 1.232 |
PSA: | 76.38000 |
LogP: | 2.29140 |
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RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.