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| CAS No.: | 109581-93-3 |
|---|---|
| Name: | TACROLIMUS |
| Molecular Structure: | |
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|
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| Formula: | C44H69NO12.H2O |
| Molecular Weight: | 822.16 |
| Synonyms: | 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- (9CI);15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;Tsukubaenolide hydrate; |
| Boiling Point: | 871.7 °C at 760 mmHg |
| Flash Point: | 481 °C |
| Hazard Symbols: |
 T
|
| Risk Codes: | 25 |
| Safety: | 45 |
| Transport Information: | UN 2811 6.1/PG 3 |
| PSA: | 187.59000 |
| LogP: | 4.51260 |
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Specification
1. Introduction of Tacrolimus monohydrate
Tacrolimus monohydrate, with its cas register number of 109581-93-3, is also called Prograf; Fk-506; Tacrolimus. Tacrolimus monohydrate (CAS NO.109581-93-3) reduces myasthenic symptoms due to its immunosuppressive properties. We studied its therapeutic effects and noted improvement in 7 of 13 myasthenic patients on the clinical muscle test. Two other patients with relapsing ocular symptoms improved. We also examined patient sensitivity to FK506, but could not predict such sensitivity before it treatment in the present study.
2. Properties of Tacrolimus monohydrate
Tacrolimus monohydrate has the following properties: (1)Flash Point: 481 °C; (2)Storage tempreture: -20 °C; (3)Enthalpy of Vaporization: 143.95 kJ/mol; (4)Boiling Point: 871.7 °C at 760 mmHg; (5)Vapour Pressure: 1.73E-35 mmHg at 25 °C.
3. Toxicity of Tacrolimus monohydrate
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intravenous | 23600ug/kg (23.6mg/kg) | Drugs in Japan Vol. -, Pg. 720, 1995. | |
| rat | LD50 | oral | 134mg/kg (134mg/kg) | Drugs in Japan Vol. -, Pg. 720, 1995. |
4. Safety Information of Tacrolimus monohydrate
Hazard Codes of Tacrolimus monohydrate (CAS NO.109581-93-3): T
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Risk Statements: 25
R25 :Toxic if swallowed.
Safety Statements: 45
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)