CAS No.113-15-5,ergotamine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	113-15-5
Name:	ergotamine
Article Data:	9

Formula:	C₃₃H₃₅N₅O₅
Molecular Weight:	581.671
Synonyms:	Ergotamine(8CI);Ergotamin;NSC 95090;
EINECS:	204-023-9
Density:	1.47 g/cm³
Melting Point:	241-249℃
Boiling Point:	914.5 °C at 760 mmHg
Flash Point:	506.9 °C
Transport Information:	UN 1544
PSA:	118.21000
LogP:	2.19540

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Chemistry

MF: C₃₃H₃₅N₅O₅
MW: 581.6615
EINECS: 204-023-9
Product Categories: Organics
Mol File: 113-15-5.mol
Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor.
Synonyms:12’-hydroxy-2’-methyl-5’alpha-(phenylmethyl)ergotaman-3’,6’,18-trione;18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-6(5’alpha)-ergotaman-3;6’,18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-ergotaman-3(5’-alph;ergotamin;ergotamine;Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α)-;Ergotamine (8CI);NSC 95090
The structure of Ergotamine(113-15-5) is:

Uses

1、Ergotamine(113-15-5) is used medicinally for treatment of acute migraine attacks (sometimes in combination with caffeine), and to induce childbirth and prevent post-partum haemorrhage.
2、In high doses ergotamine is conducive to vascular stasis, thrombosis and gangrene. It can increase uterine contractivity and occasionally is used therapeutically immediately post-partum to decrease uterine bleeding.

Toxicity Data With Reference

1.	cyt-hmn:lym 100 µg/L/24H	MUREAV Mutation Research. 48 (1977),205.
2.	ivn-rbt LD50:100 mg/kg	EXPEAM Experientia. 33 (1977),1552.
3.	scu-frg LDLo:33 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 27 (1923),459.

Consensus Reports

Ergotamine(113-15-5) is reported in EPA TSCA Inventory.

Safety Profile

Poison by intravenous and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Mechanism of action
The mechanism of action of ergotamine is complex.The molecule shares structural similarity with neurotransmitters such as serotonin, dopamine, and adrenaline and can thus bind to several receptors acting as an agonist. Ergotamine also has effects on the dopamine and noradrenaline receptors. It is its action on the D2 dopamine and 5-HT_1A receptors that can cause some side effects.