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| CAS No.: | 119418-04-1 | ||
|---|---|---|---|
| Name: | GALANIN, HUMAN | ||
| Molecular Structure: | |||
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| Formula: | C139H210N42O43 | ||
| Molecular Weight: | 3157.41 | ||
| Synonyms: | GALANIN, HUMAN;Galanin(human),1mg; | ||
| Solubility: | The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents. | ||
| Appearance: | powder | ||
| Safety: |
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| PSA: | 1367.68000 | ||
| LogP: | -2.35300 | ||
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Chemistry
Molecular Formula : C139H210N42O43
Molecular Weight : 3157.45
Product Categories: Peptide;Galanins;Neuropeptides;Peptides for Cell Biology;Galanin receptor
Sequence: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser
Solubility: The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
Storage: Store the peptide at -20°C. Keep container tightly closed.
Form: powder
Synonym: Galanin(human),1mg
The Molecular Structure of Hypocretin-2 (CAS NO.119418-04-1):
Safety Profile
WGK Germany: 3
Specification
Galanin is a neuropeptide that has not been established as a member of any known family of neuropeptides despite repeated efforts to discover related peptides. Its actions are mediated via Gi-protein-coupled receptors and ion channels, usually producing inhibition of secretion of a transmitter or hormone in the nervous and endocrine system. In many respects, these inhibitory actions of galanin remind us of those of gamma-aminobutyric acid (GABA) and of neuropeptide Y (NPY). Galanin coexists with GABA, noradrenaline, 5-hydroxytryptamine (5-HT), and NPY in several regions of the brain. Galanin is a 29-amino acid neuropeptide not homologus with any other known peptide. High concentrations of galanin and its receptor subtypes are present in the hypothalamus and central administration of the neuropeptide increases food consumption in fed rats,a highly reproducible result. Although galanin appears to play a minor role in normal feeding behavior it is possible that under abnormal physiological conditions it may exert profound effects. Preliminary reports demonstrate unusual endogenous peptide levels in human appetite disorders but other studies have been inconclusive. It is possible that more targeted investigations involving subtype-selective non-peptide galanin receptor ligands may have clinical implications in appetite disorders.