Products Categories
CAS No.: | 122-14-5 |
---|---|
Name: | Fenitrothion |
Article Data: | 14 |
Molecular Structure: | |
Formula: | C9H12NO5PS |
Molecular Weight: | 277.238 |
Synonyms: | Phosphorothioicacid, O,O-dimethyl O-(4-nitro-m-tolyl) ester (6CI,8CI);Phosphorothioicacid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester;Accothion;Agria 1050;Agriya 1050;Agrothion;Arbogal;BAY 41831;Bayer 41831;Bayer S5660;CL 47300;CP 47114;Dimethyl 4-nitro-m-tolyl phosphorothionate;EI 47300;ENT 25,715;Fenition; |
EINECS: | 204-524-2 |
Density: | 1.3227 g/cm3 |
Melting Point: | 3.4 °C |
Boiling Point: | 349.5 °C at 760 mmHg |
Flash Point: | 165.2 °C |
Solubility: | 0.003 g/100 mL in water |
Appearance: | brownish-yellow oil |
Hazard Symbols: | Xn,N |
Risk Codes: | 50/53-23-21/22-67-65-38-11 |
Safety: | 2-60-61-45-36/37-62 |
PSA: | 115.41000 |
LogP: | 3.97310 |
IUPAC Name: Dimethoxy-(3-methyl-4-nitrophenoxy)-sulfanylidene-λ5-phosphane
Synonyms of Fenitrothion (CAS NO.122-14-5): 3-Methyl-4-nitrophenyl dimethyl phosphorothioate ; Accothion ; Agrothion ; Cekutrothion ; Dimethyl (3-methyl-4-nitrophenyl) thiophosphate ; Fenitrothion ; Metathionine ; O,O-Dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate ; Phenitrothion ; m-Cresol, 4-nitro-, O-ester with O,O-dimethyl
phosphorothioate
CAS NO: 122-14-5
Molecular Formula: C9H12NO5PS
Molecular Weight: 277.23
Molecular Structure:
EINECS: 204-524-2
H bond acceptors: 6
H bond donors: 0
Freely Rotating Bonds: 5
Polar Surface Area: 115.41 Å2
Index of Refraction: 1.57
Molar Refractivity: 66.55 cm3
Molar Volume: 202.7 cm3
Surface Tension: 54 dyne/cm
Density: 1.367 g/cm3
Flash Point: 165.2 °C
Enthalpy of Vaporization: 57.06 kJ/mol
Boiling Point: 349.5 °C at 760 mmHg
Vapour Pressure: 9.44E-05 mmHg at 25°C
Melting Point: 3.4°C
Storage temp: APPROX 4°C
Water Solubility: 0.003 g/100 mL
Appearance: Brownish-yellow oil
Product Categories: INSECTICIDE;Herbicides;OrganophorousPesticides&Metabolites;Urea structure;Alpha sort;E-GAlphabetic;Pesticides&Metabolites;Alphabetic;F;FA - FLPesticides;Insecticides;Organophorous
Fenitrothion (CAS NO.122-14-5) is an organophosphate insecticide.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 11mg/kg (11mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
cat | LD50 | oral | 142mg/kg (142mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
cattle | LD50 | unreported | 217mg/kg (217mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: EXCITEMENT | Indian Journal of Animal Sciences. Vol. 49, Pg. 314, 1979. |
chicken | LD50 | oral | 280mg/kg (280mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967. |
duck | LD50 | oral | 1190mg/kg (1190mg/kg) | Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979. | |
duck | LD50 | skin | 504mg/kg (504mg/kg) | Toxicology and Applied Pharmacology. Vol. 47, Pg. 451, 1979. | |
guinea pig | LD50 | intravenous | 112mg/kg (112mg/kg) | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. | |
guinea pig | LD50 | intravenous | 112mg/kg (112mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. |
guinea pig | LD50 | oral | 500mg/kg (500mg/kg) | "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976Vol. -, Pg. -, 1971/1976. | |
mammal (species unspecified) | LD50 | unreported | 142mg/kg (142mg/kg) | "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 330, 1971. | |
man | LDLo | oral | 429uL/kg (0.429mL/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: OTHER CHANGES | Human Toxicology. Vol. 6, Pg. 403, 1987. |
mouse | LD50 | intracrebral | 1gm/kg (1000mg/kg) | Pesticide Biochemistry and Physiology. Vol. 8, Pg. 302, 1978. | |
mouse | LD50 | intraperitoneal | 280mg/kg (280mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
mouse | LD50 | oral | 229mg/kg (229mg/kg) | Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 25, Pg. 635, 1978. | |
mouse | LD50 | skin | 2500mg/kg (2500mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
mouse | LD50 | subcutaneous | 1gm/kg (1000mg/kg) | Agricultural and Biological Chemistry. Vol. 25, Pg. 605, 1961. | |
mouse | LD50 | unreported | 470mg/kg (470mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(5), Pg. 38, 1963. | |
quail | LD50 | oral | 56200ug/kg (56.2mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
rabbit | LD50 | skin | 1250mg/kg (1250mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(10), Pg. 12, 1966. | |
rat | LC50 | inhalation | 378mg/m3/4H (378mg/m3) | BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Egeszsegtudomany. Vol. 24, Pg. 173, 1980. |
rat | LD50 | intraperitoneal | 300mg/kg (300mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) | Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982. |
rat | LD50 | intratracheal | 950mg/kg (950mg/kg) | AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) BEHAVIORAL: TREMOR | Toxicology and Applied Pharmacology. Vol. 63, Pg. 91, 1982. |
rat | LD50 | intravenous | 33mg/kg (33mg/kg) | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. | |
rat | LD50 | intravenous | 33mg/kg (33mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Agricultural and Biological Chemistry. Vol. 27, Pg. 669, 1963. |
rat | LD50 | oral | 250mg/kg (250mg/kg) | Journal of Economic Entomology. Vol. 61, Pg. 743, 1968. | |
rat | LD50 | skin | 1002mg/kg (1002mg/kg) | Arquivos do Instituto Biologico, Sao Paulo. Vol. 37, Pg. 219, 1970. | |
rat | LD50 | subcutaneous | 1300mg/kg (1300mg/kg) | Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 13, Pg. 401, 1988. | |
rat | LD50 | unreported | 290mg/kg (290mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 74, Pg. 41P, 1978. | |
women | TDLo | oral | 800mg/kg (800mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Archives of Toxicology. Vol. 56, Pg. 136, 1984. |
Safety Information about Fenitrothion (CAS NO.122-14-5):
Hazard Codes: XnN,T,F
Risk Statements: 50/53-23-21/22-67-65-38-11
R11: Highly flammable.
R21/22: Harmful in contact with skin and if swallowed.
R23 : Toxic by inhalation.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
R65: Harmful: may cause lung damage if swallowed.
R67: Vapours may cause drowsiness and dizziness.
Safety Statements: 2-60-61-45-36/37-62
S2: Keep out of the reach of children.
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S60: This material and its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.
S62: If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
RIDADR: 3018
RTECS: TG0350000
HazardClass: 6.1(b)
PackingGroup: III
Health Hazard: Fenitrothion is an organophosphate insecticide. It is a highly toxic cholinesterase inhibitor, that acts on the nervous system. Does not cause delayed neurotoxicity and contact produces little irritation.
Fire Hazard: When heated to decomposition, Fenitrothion emits very toxic fumes of oxides of nitrogen, phosphorus and sulfur. Decomposition at 212-284F produces a mixture of organophosphorus polymers. Unstable in alkaline media. Stable for 2 years if stored at 68-77F. Do not store above 104F.